GRN 3′UTR+78 C>T is not associated with risk for Parkinson’s disease
Identifieur interne : 000A80 ( Main/Exploration ); précédent : 000A79; suivant : 000A81GRN 3′UTR+78 C>T is not associated with risk for Parkinson’s disease
Auteurs : B. Jasinska-Myga [États-Unis, Pologne] ; C. Wider [États-Unis] ; G. Opala [Pologne] ; A. Krygowska-Wajs [Pologne] ; M. Barcikowska [Pologne] ; K. Czyzewski [Pologne] ; M. Baker [États-Unis] ; R. Rademakers [États-Unis] ; R. J. Uitti [États-Unis] ; M. J. Farrer [États-Unis] ; O. A. Ross [États-Unis] ; Z. K. Wszolek [États-Unis]Source :
- European Journal of Neurology [ 1351-5101 ] ; 2009-08.
English descriptors
Abstract
Background and purpose: A single nucleotide polymorphism in the 3′‐untranslated region of the progranulin gene (GRN; 3′UTR+78C>T; rs5848) was reported to alter the risk for frontotemporal lobar degeneration with ubiquitin‐positive inclusions (FTLD‐U). rs5848 is located within a micro‐RNA binding site and affects the expression of GRN. Methods: As FTLD‐U patients often present with parkinsonism, we investigated the association of GRN rs5848 and risk of Parkinson’s disease in two Caucasian patient–control series (n = 1413) from the US and Poland. Results: No association was observed between rs5848 and susceptibility to Parkinson’s disease (individual series and combined analysis). Conclusions: This finding shows that GRN rs5848 does not affect the risk of Parkinson’s disease in the US and Polish populations.
Url:
DOI: 10.1111/j.1468-1331.2009.02621.x
Affiliations:
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Barcikowska</name><affiliation wicri:level="1"><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Neurodegenerative Disorders, Medical Research Center, Polish Academy of Sciences, Warsaw</wicri:regionArea><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Czyzewski, K" sort="Czyzewski, K" uniqKey="Czyzewski K" first="K." last="Czyzewski">K. Czyzewski</name><affiliation wicri:level="1"><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Neurology, MSWiA Hospital, Warsaw</wicri:regionArea><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Baker, M" sort="Baker, M" uniqKey="Baker M" first="M." last="Baker">M. 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Wszolek</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mayo Clinic, Jacksonville, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">European Journal of Neurology</title><idno type="ISSN">1351-5101</idno><idno type="eISSN">1468-1331</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2009-08">2009-08</date><biblScope unit="volume">16</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="909">909</biblScope><biblScope unit="page" to="911">911</biblScope></imprint><idno type="ISSN">1351-5101</idno></series><idno type="istex">36CD324210EE27CF8AC37920743255A43F05C594</idno><idno type="DOI">10.1111/j.1468-1331.2009.02621.x</idno><idno type="ArticleID">ENE2621</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1351-5101</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>GRN</term><term>Parkinson’s disease</term><term>SNP</term><term>genetics</term><term>miRNA</term><term>rs5848</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background and purpose: A single nucleotide polymorphism in the 3′‐untranslated region of the progranulin gene (GRN; 3′UTR+78C>T; rs5848) was reported to alter the risk for frontotemporal lobar degeneration with ubiquitin‐positive inclusions (FTLD‐U). rs5848 is located within a micro‐RNA binding site and affects the expression of GRN. Methods: As FTLD‐U patients often present with parkinsonism, we investigated the association of GRN rs5848 and risk of Parkinson’s disease in two Caucasian patient–control series (n = 1413) from the US and Poland. Results: No association was observed between rs5848 and susceptibility to Parkinson’s disease (individual series and combined analysis). Conclusions: This finding shows that GRN rs5848 does not affect the risk of Parkinson’s disease in the US and Polish populations.</div></front></TEI><affiliations><list><country><li>Pologne</li><li>États-Unis</li></country><region><li>Floride</li></region></list><tree><country name="États-Unis"><region name="Floride"><name sortKey="Jasinska Yga, B" sort="Jasinska Yga, B" uniqKey="Jasinska Yga B" first="B." last="Jasinska-Myga">B. Jasinska-Myga</name></region><name sortKey="Baker, M" sort="Baker, M" uniqKey="Baker M" first="M." last="Baker">M. Baker</name><name sortKey="Farrer, M J" sort="Farrer, M J" uniqKey="Farrer M" first="M. 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